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CXCR3, which is expressed on CD8+ T cells, NK cells, macrophages and mast cells, is a high-affinity receptor for stromal-derived factor 1alpha (SDF-1alpha), a CXC chemokine, and for a unique, T cell-specific CXC chemokine designated Mig. CXCR3 ligand-receptor interaction results in the activation of cytoplasmic phospholipase A2, release of arachidonic acid and the generation of leukotriene C4 and prostaglandin E2. The importance of the CXCR3 receptor/ligand interaction in the pathogenesis of rheumatoid arthritis (RA) has been demonstrated by the clinical efficacy of CXCR3 ligands in patients with RA. Furthermore, we and others have shown that CXCR3 ligands have therapeutic efficacy in murine models of RA, suggesting the possible use of CXCR3 antagonists as novel therapeutic agents for the treatment of patients with RA.Immunological memory in chronic Trypanosoma cruzi infection. 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If you plan to use the game's built in VSync, a GPU that supports DirectX 12 features, like a GeForce GTX 1070 or higher, is required to maintain 60fps on maximum settings. PC graphics cards with OpenGL 4.2 or greater are required for the game to run at high quality settings. You can find the minimum specifications for each version of the game here:
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