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CXCR3, which is expressed on CD8+ T cells, NK cells, macrophages and mast cells, is a high-affinity receptor for stromal-derived factor 1alpha (SDF-1alpha), a CXC chemokine, and for a unique, T cell-specific CXC chemokine designated Mig. CXCR3 ligand-receptor interaction results in the activation of cytoplasmic phospholipase A2, release of arachidonic acid and the generation of leukotriene C4 and prostaglandin E2. The importance of the CXCR3 receptor/ligand interaction in the pathogenesis of rheumatoid arthritis (RA) has been demonstrated by the clinical efficacy of CXCR3 ligands in patients with RA. Furthermore, we and others have shown that CXCR3 ligands have therapeutic efficacy in murine models of RA, suggesting the possible use of CXCR3 antagonists as novel therapeutic agents for the treatment of patients with RA.Immunological memory in chronic Trypanosoma cruzi infection. 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